The Assay Guidance manual, managed by the National Center for Advancing Translational Sciences (NCATS), is a great resource full of best practices for anyone looking to optimize assays with the goal of studying or identifying compounds that modulate various aspects of cellular biology. They recently published a chapter focused entirely on Inhibition of PPI in cell-based assays. Check it out!

https://www.ncbi.nlm.nih.gov/books/NBK464632/